Genetic testing may identify who may benefit from combination therapy (T4+T3) after thyroidectomy.
The deiodinase 2 enzyme (DIO2) in the brain is responsible for converting T4 to T3 in the brain. Sixteen percent of the population carries a variation in the DIO2 gene that may affect how they respond to thyroid therapy after thyroidectomy. These individuals show in genetic testing a “CC” type or rs225014 polymorphism in the DIO2 gene. […]